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CLASSICAL COMPLEMENT PATHWAY
Descriptors Found:
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DeCS
Descriptor
English
:
Complement Pathway, Classical
Descriptor
Spanish
:
Vía Clásica del Complemento
Descriptor
Portuguese
:
Via Clássica do Complemento
Synonyms
English
:
Classical Complement Activation Pathway
Complement Activation Pathway, Classical
Classical Complement Pathway
Tree Number:
G12.274.698
Definition
English
:
Complement activation
initiated by the binding of
COMPLEMENT C1
to ANTIGEN-ANTIBODY COMPLEXES at the
COMPLEMENT C1Q
subunit. This leads to the sequential activation of
COMPLEMENT C1R
and
COMPLEMENT C1S
subunits. Activated C1s cleaves
COMPLEMENT C4
and
COMPLEMENT C2
forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of
COMPLEMENT C5
and the assembly of
COMPLEMENT MEMBRANE ATTACK COMPLEX.
History Note
English
:
91(79); was see under COMPLEMENT ACTIVATION 1979-90
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
3217
Unique Identifier:
D003171
Occurrence in VHL
:
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